Throughout its lifetime, adult skeletal muscle will undergo several bouts of damage and repair. However, adult skeletal muscle, which is terminally differentiated, has access to a pool of stem cells, also called satellite cells,that facilitate muscle recovery after injury. Work in our lab is directed toward discovering the critical mechanisms of muscle recovery in health and disease, and we are particularly focused on diseases and conditions that are known to negatively affect the regenerative capacity of adult skeletal muscle (e.g., aging and muscular dystrophy). Current research in the laboratory is directed toward understanding how healthy populations of mitochondria contribute to muscle’s ability to recovery after muscle injury. We utilize transgenic and knockout mouse models to test sufficiency and necessity of key proteins involved in mitochondrial maintenance. Moving forward, we are interested in identifying therapeutic modalities to improve mitochondrial populations in skeletal muscle in an effort to also improve regeneration in diseased muscle.
- Muscle Biology & Biochemistry
- Molecular Biology of Exercise
- Publications by Jarrod Call may be found at PubMed.