Lee's research focuses on understanding how inflammation influences neurodegenerative diseases. Chronic inflammation in the CNS has been strongly implicated in the pathophysiology of many neurodegenerative diseases. Microglia are primarily responsible for innate immune surveillance in the CNS. The surveillance properties of microglia are essential for the maintenance of central nerve system (CNS) integrity, however, prolonged, excessive and uncontrolled microglial activation has severe and deleterious consequences. Especially, microglia activation is heavily implicated in the pathogenesis of most CNS diseases, including Alzheimer’s and Parkinson’s disease (PD), multiple sclerosis (MS). Lee's research interest has been in finding the key intrinsic molecules regulating immune responses in CNS.
- Parkinson’s disease
- Neurodegenerative diseases
- Regulator G-protein signaling (RGS) proteins
- Experimental autoimmune encephalomyelitis (EAE)
- Publications by Jae-Kyung (Jamise) Lee may be found at PubMed.