Jae-Kyung Lee

Associate Professor
  • Post-doctoral fellow University of Texas Southwestern Medical Center 2008
  • Ph.D. University of North Texas Health Science Center 2005
  • B.S / M.S. Kyungpook National University 1999

In the Lab

Lee’s research focuses on understanding how inflammation influences neurodegenerative diseases. Chronic inflammation in the CNS has been strongly implicated in the pathophysiology of many neurodegenerative diseases. Microglia are primarily responsible for innate immune surveillance in the CNS. The surveillance properties of microglia are essential for the maintenance of central nerve system (CNS) integrity, however, prolonged, excessive and uncontrolled microglial activation has severe and deleterious consequences. Especially, microglia activation is heavily implicated in the pathogenesis of most CNS diseases, including Alzheimer’s and Parkinson’s disease (PD), multiple sclerosis (MS). Lee’s research interest has been in finding the key intrinsic molecules regulating immune responses in CNS.

Research Interest

  • ​Neuroinflammation
  • Parkinson’s disease
  • Neurodegenerative diseases
  • Regulator G-protein signaling (RGS) proteins
  • Experimental autoimmune encephalomyelitis (EAE)