Scientists have captured a seizure moving through a living brain in three dimensions and in real time, offering one of the clearest views yet of how abnormal electrical activity spreads through neural tissue. Using a newly developed high-resolution light-sheet microscope, researchers at the University of Georgia’s Regenerative Bioscience Center recorded the progression of a seizure in a zebrafish larva from its apparent origin to its eventual disappearance. The advance could help neuroscientists understand how seizures begin, why they travel through particular brain regions and how they might be stopped before they develop into more serious neurological events.
Peter Kner, a professor in the University of Georgia’s College of Engineering and the study’s corresponding author, emphasized the limitations of relying on two-dimensional images to understand a three-dimensional brain. A single optical plane may show a….(READ MORE ON BIOENGINEER )
