Animal Models of Injury and Disease
-
In the Lab According to the CDC, chronic diseases such as cardiovascular disease and cancer account for seven of the 10 leading causes of death in the U.S. Advanced age is a common and significant risk factor for chronic diseases, and as the population rapidly ages in the coming decades, the prevalence of those diseases…
-
In the Lab The Mortensen Lab is interested in using engineering approaches to solve important biological problems where canonical techniques and methods of thinking have failed. This requires a multidisciplinary mindset to draw together microscopy, engineering, systems level biology, and regenerative medicine. Specifically, our research uses multiphoton microscopy to enable the design of next generation…
-
In the Lab Interleukin-1 beta (IL-1ß) is a cytokine that is produced by the immune system and a variety of cells in response to an insult. Previous work in our lab has demonstrated that this cytokine is capable of affecting specific neurotransmitter systems in specific parts of the brain by crossing the blood brain barrier…
-
Bio Dr. P. S. MohanKumar was born in Tamil Nadu, India. He received his veterinary degree from the Madras Veterinary College, Chennai, India. He went onto pursue a PhD degree in neuroendocrinology at Kansas State University following it with a stint of postdoctoral fellowship at University of Kansas Medical Center. After a brief period as…
-
In the Lab Functional heterogeneity is a significant barrier to the clinical translation of many cellular therapies, including mesenchymal stromal cells (MSCs). Though MSCs have shown promise in treatment of immune diseases, the mechanisms of action and critical quality attributes (CQAs, predictors of function) in different therapeutic settings are largely unknown. The overall goal of the…
-
In the Lab Dr. Kanthasamy’s research program has been at the forefront in unraveling the cell signaling mechanisms underlying key pathophysiological processes of PD, including mitochondrial dysfunction, oxidative stress, dopaminergic therapy, aSyn protein aggregation, gut microbiota dysbiosis, exosome trafficking, neuroinflammation, and apoptosis. Furthermore he and his team recently adopted a highly sensitive RT-QuIC assay to…
-
Post-doctoral fellow University of Texas Southwestern Medical Center 2008 Ph.D. University of North Texas Health Science Center 2005 B.S / M.S. Kyungpook National University 1999 In the Lab Lee’s research focuses on understanding how inflammation influences neurodegenerative diseases. Chronic inflammation in the CNS has been strongly implicated in the pathophysiology of many neurodegenerative diseases. Microglia…