Stem Cell Therapy
-
In the Lab Functional heterogeneity is a significant barrier to the clinical translation of many cellular therapies, including mesenchymal stromal cells (MSCs). Though MSCs have shown promise in treatment of immune diseases, the mechanisms of action and critical quality attributes (CQAs, predictors of function) in different therapeutic settings are largely unknown. The overall goal of the…
-
Post-doctoral fellow University of California Los Angeles, 2010 PhD Pennsylvania State University, 2002 M.S. Pennsylvania State University, 1998 B.S. Konkuk University, 1992 In the Lab Mesenchymal Stem Cells (MSCs) are powerful multipotent progenitor cells that are present in many tissues, such as blood, bone, adipose tissue, muscle, and cartilage. MSCs exist during embryonic development and…
-
Ph.D. Biochemistry, Virginia Commonwealth University 2008 M.S. Biology, Virginia Commonwealth University 2005 B.S., Biology, College of William and Mary 2002 In the Lab Medical treatments such as chemotherapies, exposure to environmental and industrial toxicants, and injury have all been shown to cause male factor infertility resulting in a complete loss of sperm production. To date,…
-
In the Lab Chromatin configuration in the nucleus or germinal vesicle (GV) of mammalian oocytes undergoes dynamic epigenetic modifications during oocyte growth. A crucial developmental transition at the culmination of oogenesis, large-scale chromatin remodeling in the GV is essential to confer the female gamete with meiotic and developmental potential. Using several models for the experimental…
-
In the Lab Throughout its lifetime, adult skeletal muscle will undergo several bouts of damage and repair. However, adult skeletal muscle, which is terminally differentiated, has access to a pool of stem cells, also called satellite cells,that facilitate muscle recovery after injury. Work in our lab is directed toward discovering the critical mechanisms of muscle…